منابع مشابه
BK Channel News
The large conductance Ca 2 -activated K channel (BK Ca ) is well positioned to assume diverse physiological functions because it is ubiquitously expressed in many cell types. Some of the functions recently proposed for this channel offer unexpected surprises, however, such as a role in innate immunity in neutrophil leukocytes (Ahluwalia et al., 2004), recognition as a heme-binding protein (Tang...
متن کاملEnhancement Effects of Martentoxin on Glioma BK Channel and BK Channel (α+β1) Subtypes
BACKGROUND BK channels are usually activated by membrane depolarization and cytoplasmic Ca(2+). Especially,the activity of BK channel (α+β4) can be modulated by martentoxin, a 37 residues peptide, with Ca(2+)-dependent manner. gBK channel (glioma BK channel) and BK channel (α+β1) possessed higher Ca(2+) sensitivity than other known BK channel subtypes. METHODOLOGY AND PRINCIPAL FINDINGS The p...
متن کاملOpen Channel for News
Stuff happens. That’s one of life’s rules. Some of it is of profound importance or even historical in nature. Some is routine or of no major significance. The rest depends on who you are, what you are doing, or where you are or where you are going. But, regardless, learning about what’s happening in the world gives us awareness and allows us to assess implications, make decisions, and respond w...
متن کاملBK channel activation: structural and functional insights.
The voltage- and Ca(2+)-activated K(+) (BK) channels are involved in the regulation of neurotransmitter release and neuronal excitability. Structurally, BK channels are homologous to voltage- and ligand-gated K(+) channels, having a voltage sensor and pore as the membrane-spanning domain and a cytosolic domain containing metal binding sites. Recently published electron cryomicroscopy (cryo-EM) ...
متن کاملSingle-channel kinetics of BK (Slo1) channels
Single-channel kinetics has proven a powerful tool to reveal information about the gating mechanisms that control the opening and closing of ion channels. This introductory review focuses on the gating of large conductance Ca(2+)- and voltage-activated K(+) (BK or Slo1) channels at the single-channel level. It starts with single-channel current records and progresses to presentation and analysi...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2004
ISSN: 1540-7748,0022-1295
DOI: 10.1085/jgp.200409069